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Gene ENSMUSG00000021048 (Mthfd1)
Chromosomal location
Chr 12: 77356395 - 77420789 (+)
Description
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Gene [Source:MGI Symbol;Acc:MGI:1342005]
RefSeq_dna
NM_138745 
RefSeq_peptide
NP_620084.1 
UniGene
Mm.29584 Mm.472060 
MGI
MGI:1342005 
Uniprot/SWISSPROT
Q922D8 
Uniprot/SPTREMBL
Q3TW74 Q3UZH3 Q8BXX7 Q8BY49 Q8R013 
Human Ortholog
ENSG00000100714 (MTHFD1)
Omim 172460 - METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1  601634 - NEURAL TUBE DEFECTS, FOLATE-SENSITIVE  
UniTrap UNI14797
Vector Insertion
Chr 12: 77356532 - 77371404
Public Clones (sanger) P135B03 (ggtc) P142D11 (ggtc) PST4843-NL (escells) PST4843-NR (escells)
PST14744-NR (escells) IST10827A9 (tigm) IST10993E3 (tigm) IST10200D8 (tigm)
IST14382C3 (tigm) IST13733F11 (tigm) IST14364G8 (tigm) IST14635C6 (tigm)
Private Clones OST270265 (lexicon) OST207600 (lexicon) OST51000 (lexicon)
Severity of mutation (?) Insertion after 1% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI8270
Vector Insertion
Chr 12: 77371490 - 77380390
Public Clones (sanger) RRF140 (baygenomics)
Private Clones OST464134 (lexicon) OST339126 (lexicon) OST212382 (lexicon)
Severity of mutation (?) Insertion after 5% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI25867
Vector Insertion
Chr 12: 77380451 - 77381143
Public Clones not available
Private Clones OST156401 (lexicon)
Severity of mutation (?) Insertion after 7% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI25769
Vector Insertion
Chr 12: 77381198 - 77381366
Public Clones not available
Private Clones OST166876 (lexicon)
Severity of mutation (?) Insertion after 9% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI7702
Vector Insertion
Chr 12: 77385031 - 77389867
Public Clones RRS225 (baygenomics)
Private Clones not available
Severity of mutation (?) Insertion after 26% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI717
Vector Insertion
Chr 12: 77392105 - 77394377
Public Clones DB0104 (sanger) BGC393 (baygenomics) W073E07 (ggtc) W066C06 (ggtc)
W066D04 (ggtc) W074B04 (ggtc)
Private Clones not available
Severity of mutation (?) Insertion after 45% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI14503
Vector Insertion
Chr 12: 77395417 - 77398468
Public Clones FHCRC-GT-S9-7C1 (fhcrc)
Private Clones not available
Severity of mutation (?) Insertion after 53% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI2685
Vector Insertion
Chr 12: 77404969 - 77408208
Public Clones AL0452 (sanger)
Private Clones not available
Severity of mutation (?) Insertion after 76% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI10372
Vector Insertion
Chr 12: 77416089 - 77418593
Public Clones XB175 (baygenomics)
Private Clones OST339845 (lexicon) OST28679 (lexicon)
Severity of mutation (?) Insertion after 97% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI20310
Vector Insertion
Chr 12: 77418688 - 77420567
Public Clones not available
Private Clones OST367625 (lexicon)
Severity of mutation (?) Insertion after 100% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

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