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Gene ENSMUSG00000026866 (Kynu)
Chromosomal location
Chr 2: 43410849 - 43538235 (+)
Description
kynureninase (L-kynurenine hydrolase) Gene [Source:MGI (curated);Acc:Kynu-001]
RefSeq_dna
NM_027552 
RefSeq_peptide
NP_081828.1 
MGI
MGI:1918039 
Uniprot/SWISSPROT
Q9CXF0 
Uniprot/SPTREMBL
Q3V3G5 A2ARD7 Q8R0F7 Q6NSV5 A2ARD6 
Human Ortholog
ENSG00000115919 (KYNU)
Omim 236800 - HYDROXYKYNURENINURIA  
UniTrap UNI34067
Vector Insertion
Chr 2: 43484572 - 43487065
Public Clones IST12615B6 (tigm)
Private Clones not available
Severity of mutation (?) Insertion after 60% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

Show all transcripts and translations:
Transcript ENSMUST00000100129
Sequence
AGTTCTTTGGCTAGCTGGGGACAAAGAAAGATCCAGCATCCTCTGAGAAGGTACTGAAGACTACTGTCTGGATCTGAGCAG ATAACAGTTTATGATGGA

GCCTTCGCCTCTTGAGCTTCCAGTTGATGCAGTGCGGCGCATCGCGGCTGAACTCAATTGTGACCCAACAGATGAGAGGGTTGCTCTCCGCTTGGATGAG

GAAGATAAACTGAGTCATTTTAGGAACTGTTTTTATATTCCCAAAATGCGGGACCTGCCTTCAA TTGATCTATCTTTAGTGAGTGAGGATGATGATGCC

ATCTATTTCCTGGGAAATTCCCTTGGCCTTCAACCGAAAATGGTTAGGACATACCTGGAGGAAGAACTAGATAAGTGGGCCAAGAT GGGAGCCTATGGC

CATGATGTAGGCAAACGCCCTTGGATTGTAGGGGATGAGAGTATTGTAAGCCTTATGAAGGACATTGTAG GAGCCCATGAGAAAGAAATAGCTCTAATG

AATGCTTTGACTATTAATTTACATCTCCTGCTG TTATCATTCTTTAAGCCTACTCCAAAGCGGCACAAAATTCTTCTAGAAGCCAAAGCCTTCCCTTCT

GATCAT TATGCTATTGAGTCACAGATTCAACTTCACGGACTTGATGTTGAGAAAAGTATGCGGATGGTAAAGCCACGAGAG GGGGAAGAGACCTTAAG

GATGGAGGACATACTGGAAGTAATCGAGGAGGAAGGAGACTCGATCGCCGTGATCCTGTTCAGTGGGCTGCACTTTTATACTGGACAGCTGTTCAACATT

CCTGCCATAACAAAAGCTGGACATGCAAAG - UNI34067 - TATTTAAATTCAGGAGCTGGAGGTCTGGCTGGTGCCTTTGTCCACGAGAAACATGC

TCATACTGTCAAGCCTGC GTTAGTGGGATGGTTCGGCCATGACCTCAGTACAAGGTTTAACATGGATAACA AACTACAATTAATCCCCGGGGCCAATG

GATTCCGAATTTCAAACCCTCCCATTTTGTTGGTCTGCTCCTTGCACGCCAGTTTAGAG ATACAAATGGACTACTACGAGTGGACACTTTGCCCTCCAC

ATGCATAG
Translation
 MMEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSI IDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAK

M MGAYGHDVGKRPWIVGDESIVSLMKDIVG GAHEKEIALMNALTINLHLLL LSFFKPTPKRHKILLEAKAFPSDH YAIESQIQLHGLDVEKSMRMV

KPRE GEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAK - UNI34067 - YLNSGAGGLAGAFVHEKHAHTVKPA ALVGWF

GHDLSTRFNMDNK KLQLIPGANGFRISNPPILLVCSLHASLE IQMDYYEWTLCPPHA
Transcript ENSMUST00000050511
Sequence
AGTTCTTTGGCTAGCTGGGGACAAAGAAAGATCCAGCATCCTCTGAGAAGGTACTGAAGACTACTGTCTGGATCTGAGCAG ATAACAGTTTATGATGGA

GCCTTCGCCTCTTGAGCTTCCAGTTGATGCAGTGCGGCGCATCGCGGCTGAACTCAATTGTGACCCAACAGATGAGAGGGTTGCTCTCCGCTTGGATGAG

GAAGATAAACTGAGTCATTTTAGGAACTGTTTTTATATTCCCAAAATGCGGGACCTGCCTTCAA TTGATCTATCTTTAGTGAGTGAGGATGATGATGCC

ATCTATTTCCTGGGAAATTCCCTTGGCCTTCAACCGAAAATGGTTAGGACATACCTGGAGGAAGAACTAGATAAGTGGGCCAAGAT GGGAGCCTATGGC

CATGATGTAGGCAAACGCCCTTGGATTGTAGGGGATGAGAGTATTGTAAGCCTTATGAAGGACATTGTAG GAGCCCATGAGAAAGAAATAGCTCTAATG

AATGCTTTGACTATTAATTTACATCTCCTGCTG TTATCATTCTTTAAGCCTACTCCAAAGCGGCACAAAATTCTTCTAGAAGCCAAAGCCTTCCCTTCT

GATCAT TATGCTATTGAGTCACAGATTCAACTTCACGGACTTGATGTTGAGAAAAGTATGCGGATGGTAAAGCCACGAGAG GGGGAAGAGACCTTAAG

GATGGAGGACATACTGGAAGTAATCGAGGAGGAAGGAGACTCGATCGCCGTGATCCTGTTCAGTGGGCTGCACTTTTATACTGGACAGCTGTTCAACATT

CCTGCCATAACAAAAGCTGGACATGCAAAG GGCTGTTTTGTTGGCTTTGACCTAGCACATGCAGTTGGAAATGTTGAACTCCGCTTACATGACTGGGGT

GTTGACTTTGCCTGCTGGTGTTCCTATAAG - UNI34067 - TATTTAAATTCAGGAGCTGGAGGTCTGGCTGGTGCCTTTGTCCACGAGAAACATGC

TCATACTGTCAAGCCTGC GATGGACGACCTGCAGTGTGATATCAAGCTGAAAGGCAACCTGTTTGCATATGGACAGAGGAGAAAGTAA
Translation
 MMEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSI IDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAK

M MGAYGHDVGKRPWIVGDESIVSLMKDIVG GAHEKEIALMNALTINLHLLL LSFFKPTPKRHKILLEAKAFPSDH YAIESQIQLHGLDVEKSMRMV

KPRE GEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAK GCFVGFDLAHAVGNVELRLHDWGVDFACWCSYK - UNI34067 

- YLNSGAGGLAGAFVHEKHAHTVKPA AMDDLQCDIKLKGNLFAYGQRRK
Transcript ENSMUST00000112826
Sequence
GCTGGGGACAAAGAAAGATCCAGCATCCTCTGAGAAGGTACTGAAGACTACTGTCTGGATCTGAGCAG ATAACAGTTTATGATGGAGCCTTCGCCTCTT

GAGCTTCCAGTTGATGCAGTGCGGCGCATCGCGGCTGAACTCAATTGTGACCCAACAGATGAGAGGGTTGCTCTCCGCTTGGATGAGGAAGATAAACTGA

GTCATTTTAGGAACTGTTTTTATATTCCCAAAATGCGGGACCTGCCTTCAA TTGATCTATCTTTAGTGAGTGAGGATGATGATGCCATCTATTTCCTGG

GAAATTCCCTTGGCCTTCAACCGAAAATGGTTAGGACATACCTGGAGGAAGAACTAGATAAGTGGGCCAAGAT GGGAGCCTATGGCCATGATGTAGGCA

AACGCCCTTGGATTGTAGGGGATGAGAGTATTGTAAGCCTTATGAAGGACATTGTAG GAGCCCATGAGAAAGAAATAGCTCTAATGAATGCTTTGACTA

TTAATTTACATCTCCTGCTG TTATCATTCTTTAAGCCTACTCCAAAGCGGCACAAAATTCTTCTAGAAGCCAAAGCCTTCCCTTCTGATCAT TATGCT

ATTGAGTCACAGATTCAACTTCACGGACTTGATGTTGAGAAAAGTATGCGGATGGTAAAGCCACGAGAG GGGGAAGAGACCTTAAGGATGGAGGACATA

CTGGAAGTAATCGAGGAGGAAGGAGACTCGATCGCCGTGATCCTGTTCAGTGGGCTGCACTTTTATACTGGACAGCTGTTCAACATTCCTGCCATAACAA

AAGCTGGACATGCAAAG GGCTGTTTTGTTGGCTTTGACCTAGCACATGCAGTTGGAAATGTTGAACTCCGCTTACATGACTGGGGTGTTGACTTTGCCT

GCTGGTGTTCCTATAAG - UNI34067 - TATTTAAATTCAGGAGCTGGAGGTCTGGCTGGTGCCTTTGTCCACGAGAAACATGCTCATACTGTCAAG

CCTGC GTTAGTGGGATGGTTCGGCCATGACCTCAGTACAAGGTTTAACATGGATAACA AACTACAATTAATCCCCGGGGCCAATGGATTCCGAATTTC

AAACCCTCCCATTTTGTTGGTCTGCTCCTTGCACGCCAGTTTAGAG GTCTTTCAGCAAGCAACTATGACTGCGCTGAGAAGAAAATCCATTCTGCTGAC

AGGTTATCTGGAATACATGCTCAAACATTACCACAGCAAAGATAACACCGAAAACAAGGGGCCGATTGTGAATATCATCACCCCGTCCAGAGCAGAGGAG

CGTGGCTGCCAGTTAACACTCACCTTTTCCATTCCCAAGAAAAGCGTTTTTAAGGAACTAGAAAAAAGAGGAGTCGTTGTATGTATATAAATTTATGTCT

TGCATTTCACCACGCTTTCTCTCTGGGTTCCAGGTTGGGATGAGTCTTAGGTTACTAAACTTATCCTTTTATTGCATATCCTTCTAGTCAACCAATCAAG

ACAAGTCAGACATCAACTTAGCACTCAGCGTTAGCCCTGATGGATGGCTACAAGAGCCCATGGTCATTTCTGATCAAAGGGAATAAATAGCAAATCTTGC

TTTTGAAAAATA
Translation
 MMEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSI IDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAK

M MGAYGHDVGKRPWIVGDESIVSLMKDIVG GAHEKEIALMNALTINLHLLL LSFFKPTPKRHKILLEAKAFPSDH YAIESQIQLHGLDVEKSMRMV

KPRE GEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAK GCFVGFDLAHAVGNVELRLHDWGVDFACWCSYK - UNI34067 

- YLNSGAGGLAGAFVHEKHAHTVKPA ALVGWFGHDLSTRFNMDNK KLQLIPGANGFRISNPPILLVCSLHASLE VFQQATMTALRRKSILLTGYLE

YMLKHYHSKDNTENKGPIVNIITPSRAEERGCQLTLTFSIPKKSVFKELEKRGVVVCI
Transcript ENSMUST00000028223
Sequence
AGTTCTTTGGCTAGCTGGGGACAAAGAAAGATCCAGCATCCTCTGAGAAGGTACTGAAGACTACTGTCTGGATCTGAGCAG ATAACAGTTTATGATGGA

GCCTTCGCCTCTTGAGCTTCCAGTTGATGCAGTGCGGCGCATCGCGGCTGAACTCAATTGTGACCCAACAGATGAGAGGGTTGCTCTCCGCTTGGATGAG

GAAGATAAACTGAGTCATTTTAGGAACTGTTTTTATATTCCCAAAATGCGGGACCTGCCTTCAA TTGATCTATCTTTAGTGAGTGAGGATGATGATGCC

ATCTATTTCCTGGGAAATTCCCTTGGCCTTCAACCGAAAATGGTTAGGACATACCTGGAGGAAGAACTAGATAAGTGGGCCAAGAT GGGAGCCTATGGC

CATGATGTAGGCAAACGCCCTTGGATTGTAGGGGATGAGAGTATTGTAAGCCTTATGAAGGACATTGTAG GAGCCCATGAGAAAGAAATAGCTCTAATG

AATGCTTTGACTATTAATTTACATCTCCTGCTG TTATCATTCTTTAAGCCTACTCCAAAGCGGCACAAAATTCTTCTAGAAGCCAAAGCCTTCCCTTCT

GATCAT TATGCTATTGAGTCACAGATTCAACTTCACGGACTTGATGTTGAGAAAAGTATGCGGATGGTAAAGCCACGAGAG GGGGAAGAGACCTTAAG

GATGGAGGACATACTGGAAGTAATCGAGGAGGAAGGAGACTCGATCGCCGTGATCCTGTTCAGTGGGCTGCACTTTTATACTGGACAGCTGTTCAACATT

CCTGCCATAACAAAAGCTGGACATGCAAAG GGCTGTTTTGTTGGCTTTGACCTAGCACATGCAGTTGGAAATGTTGAACTCCGCTTACATGACTGGGGT

GTTGACTTTGCCTGCTGGTGTTCCTATAAG - UNI34067 - TATTTAAATTCAGGAGCTGGAGGTCTGGCTGGTGCCTTTGTCCACGAGAAACATGC

TCATACTGTCAAGCCTGC GTTAGTGGGATGGTTCGGCCATGACCTCAGTACAAGGTTTAACATGGATAACA AACTACAATTAATCCCCGGGGCCAATG

GATTCCGAATTTCAAACCCTCCCATTTTGTTGGTCTGCTCCTTGCACGCCAGTTTAGAG GTCTTTCAGCAAGCAACTATGACTGCGCTGAGAAGAAAAT

CCATTCTGCTGACAGGTTATCTGGAATACATGCTCAAACATTACCACAGCAAAGATAACACCGAAAACAAGGGGCCGATTGTGAATATCATCACCCCGTC

CAGAGCAGAGGAGCGTGGCTGCCAGTTAACACTCACCTTTTCCATTCCCAAGAAAAGCGTTTTTAAGGAACTAGAAAAAAGAGGAGTCGTT TGTGACAA

GCGAGAACCAGATGGCATCCGCGTGGCCCCTGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAGTTCATCAGACTGCTCACTTCCATACTCGACTCT

TCAGAAAGAAGCTAGCTATATTTTCTAGCACAACTCAAGTAAATCTCACTGAAAGGTGATGGAGTTTTCACTTCTATTGAATTTTAGTCATTAAAAAAAT

CTCCAGAAATTGATTGCACAGAAATGATAACTATAAAAAAATTTACATAAAACCTGGTGCATGCTTTAATATCTGTGTTTCTGGGGAACGTGGTGTCCTG

TGAATTATGAAGTCACACTTTACATGACTACAGCCTACAGATGACTGTCTTGATCAGTTGTCACATTTCATGCTCACTGAAACATTTTCTCTTTAATTTG

TGACTGAATTTCCAACGTTATAATGTATATGGACTTCTTGTATAAATATTAGAAGTATTACTTTAATTTTGCTATAGAGTTTTATTTTAATATTTGTAAC

TGAATCATCTGAAATATGTTTGATATGATCATGTTTTATCTAATTCCAGGAGGGGAACAGCCTTTTAAGCTGTTACAAAATCTCTCTCTCTCTCTCTCTC

TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCCCCCCCCCAGTGGTGTGTGTGTCTATGTGTTTGTGTTTCTGTGTGTCTGTGTAA

AGGACATGTAAGTGCTTATGTATAAGGGATGAGGTACTTGACCCTATGTACTCTTGTGAGGCCAGAGGTCAACACTGGACATCTTCCTCAATCACTGTTT

AAAATTTTATTTATTTATTTATTTTTATGTGTATGGGTATTTTGACTGCATTTATGTCTGTACCTCATGTGCATGCCATGATTACAGAAACTAGAAGATA

CATCAGATCACCTGAGACTGGAGTTACAGAGCTGCTGTGTGGATACTAGGAATTGAACCCAGGTCGTTTGGAAGAATAGCCAACGCTCTTATTCTTTGAC

ACATCTCTCCAGCCTTTCCACTTCATATTTCAATACATGATTTCTCCCCAAACCTGGAACTTGCTCCTTCAGCTCGTGTGGCTGGCCAGTGAGTCTTCAG

CGTTTCTCTGTCTCTGCCCTACAATGAATGCGGGTTACAGCTGTACACTGTTGCACATAGATTTTTTACATGTCTACTGTGATCTGAACACAGTCCTTAT

ATCAGTTCAGCAACCACTTCATCGACCAAGCAATCCCCCAGTCATTGCTTTTTTGATGCCACTACTAGTATGCATTTACTGGCAAAGAATTCTAAGTTTG

TATGTAGAAAGAAAAAGTTATAATGATTTGATAAACTTGAATAAAACATACTTGGTCAG
Translation
 MMEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLSHFRNCFYIPKMRDLPSI IDLSLVSEDDDAIYFLGNSLGLQPKMVRTYLEEELDKWAK

M MGAYGHDVGKRPWIVGDESIVSLMKDIVG GAHEKEIALMNALTINLHLLL LSFFKPTPKRHKILLEAKAFPSDH YAIESQIQLHGLDVEKSMRMV

KPRE GEETLRMEDILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAITKAGHAK GCFVGFDLAHAVGNVELRLHDWGVDFACWCSYK - UNI34067 

- YLNSGAGGLAGAFVHEKHAHTVKPA ALVGWFGHDLSTRFNMDNK KLQLIPGANGFRISNPPILLVCSLHASLE VFQQATMTALRRKSILLTGYLE

YMLKHYHSKDNTENKGPIVNIITPSRAEERGCQLTLTFSIPKKSVFKELEKRGVV CDKREPDGIRVAPVPLYNSFHDVYKFIRLLTSILDSSERS

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