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Gene ENSMUSG00000070544 (Top1)
Chromosomal location
Chr 2: 160471633 - 160548497 (+)
Description
topoisomerase (DNA) I Gene [Source:MGI (curated);Acc:Top1-001]
RefSeq_dna
NM_009408 
RefSeq_peptide
NP_033434.2 
UniGene
Mm.217233 Mm.432626 
MGI
MGI:98788 
Uniprot/SWISSPROT
Q04750 
Uniprot/SPTREMBL
Q3TPX7 Q3TSR2 Q3TUS4 Q3ULF5 Q569Q5 Q6LBJ1 
Human Ortholog
ENSG00000198900 (TOP1)
Omim not available
UniTrap UNI5501
Vector Insertion
Chr 2: 160471999 - 160472343
Public Clones XB046A (baygenomics) YTA037 (baygenomics) BGC489 (baygenomics) (ggtc)
A035B06 (ggtc) P063G02 (ggtc) W176D01 (ggtc) P088D12 (ggtc)
Private Clones not available
Severity of mutation (?) Insertion after 1% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI37
Vector Insertion
Chr 2: 160472369 - 160495269
Public Clones GC0285 (tigem) (sanger) YHB053 (baygenomics) XH392 (baygenomics) BGC417 (baygenomics)
YHC086 (baygenomics) YHA318 (baygenomics) P124G09 (ggtc) P081B06 (ggtc)
A044E07 (ggtc) P102H12 (ggtc) E069E01 (ggtc) D184D01 (ggtc) D094A02 (ggtc)
D033B01 (ggtc) 5SP124G09 (ggtc) Q017D01 (ggtc) P145E01 (ggtc) P094F06 (ggtc)
E037H06 (ggtc) D184C03 (ggtc) D051C04 (ggtc) D022D11 (ggtc) D029B04 (ggtc)
W258D01 (ggtc) P122C09 (ggtc) E112E12 (ggtc) E024E10 (ggtc) D155B12 (ggtc)
D045B03 (ggtc) D014H10 (ggtc) P017B02 (ggtc) P098F08 (ggtc) E044C02 (ggtc)
D074E10 (ggtc) Q010D04 (ggtc) P124D03 (ggtc) E120G05 (ggtc) D160C06 (ggtc)
D017A01 (ggtc) P113G04 (ggtc) W269B05 (ggtc) E082G10 (ggtc) E019B04 (ggtc)
D103F08 (ggtc) D037B01 (ggtc) D014E03 (ggtc) 5SE289C05 (ggtc) W264E06 (ggtc)
D022F09 (ggtc) D017H11 (ggtc) P013H12 (ggtc) E120G04 (ggtc) E024F10 (ggtc)
D158G07 (ggtc) PST468 (escells) PST12265-NL (escells) PST10648-NR (escells)
PST9202-NR (escells) PST1486-3 (escells) PST16175-NR (escells) PST12178-NL (escells)
PST4672-NL (escells) PST14392-NR (escells) PST11684-NR (escells) IST12589F3 (tigm)
IST13574A9 (tigm) IST10359A1 (tigm) IST10872D9 (tigm) IST14037A11 (tigm)
IST10341B4 (tigm) IST14987A3 (tigm) IST13921F1 (tigm) IST14995A10 (tigm)
IST11186C7 (tigm) IST11394G4 (tigm) IST12763F4 (tigm) IST14965F1 (tigm)
IST11586A12 (tigm) IST12923A7 (tigm) IST10608B10 (tigm) IST14079D5 (tigm)
IST14733C5 (tigm) IST11419F8 (tigm) IST10983G6 (tigm) IST14741F6 (tigm)
IST14718B11 (tigm) IST10550H5 (tigm) IST13830G8 (tigm) IST11417D11 (tigm)
IST12195H12 (tigm) IST10845D4 (tigm) IST13904D9 (tigm)
Private Clones not available
Severity of mutation (?) Insertion after 3% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI14576
Vector Insertion
Chr 2: 160495293 - 160495827
Public Clones FHCRC-GT-S8-5F1 (fhcrc) FHCRC-GT-S3-6A1 (fhcrc) IST13021F7 (tigm)
Private Clones OST473153 (lexicon) OST469796 (lexicon) OST464924 (lexicon) OST462517 (lexicon)
OST461755 (lexicon) OST460111 (lexicon) OST458583 (lexicon) OST440537 (lexicon)
OST430531 (lexicon) OST427212 (lexicon) OST427189 (lexicon) OST421466 (lexicon)
OST420449 (lexicon) OST413991 (lexicon) OST413854 (lexicon) OST413698 (lexicon)
OST409705 (lexicon) OST406836 (lexicon) OST406202 (lexicon) OST395467 (lexicon)
OST380352 (lexicon) OST374360 (lexicon) OST371706 (lexicon) OST366840 (lexicon)
OST365352 (lexicon) OST364167 (lexicon) OST363699 (lexicon) OST363590 (lexicon)
OST362291 (lexicon) OST361755 (lexicon) OST358292 (lexicon) OST352828 (lexicon)
OST350917 (lexicon) OST350773 (lexicon) OST332277 (lexicon) OST329944 (lexicon)
OST328912 (lexicon) OST327656 (lexicon) OST321908 (lexicon) OST316921 (lexicon)
OST235079 (lexicon) OST206240 (lexicon) OST173103 (lexicon) OST128646 (lexicon)
OST115725 (lexicon) OST109850 (lexicon) OST108363 (lexicon) OST85776 (lexicon)
OST68270 (lexicon) OST66893 (lexicon) OST66185 (lexicon) OST63766 (lexicon)
OST63562 (lexicon) OST62135 (lexicon) OST60322 (lexicon) OST59536 (lexicon)
OST59250 (lexicon) OST58666 (lexicon) OST58663 (lexicon) OST53658 (lexicon)
OST53636 (lexicon) OST47520 (lexicon) OST45659 (lexicon) OST45025 (lexicon)
OST42042 (lexicon) OST41848 (lexicon) OST39594 (lexicon) OST38595 (lexicon)
OST38024 (lexicon) OST35805 (lexicon) OST34732 (lexicon) OST33957 (lexicon)
OST33940 (lexicon) OST33899 (lexicon) OST32135 (lexicon)
Severity of mutation (?) Insertion after 3% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI11915
Vector Insertion
Chr 2: 160495835 - 160495939
Public Clones Q021E03 (ggtc)
Private Clones not available
Severity of mutation (?) Insertion after 3% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI16447
Vector Insertion
Chr 2: 160495939 - 160508386
Public Clones IST14706E4 (tigm) IST11621C2 (tigm)
Private Clones OST461133 (lexicon) OST457052 (lexicon) OST440559 (lexicon) OST400220 (lexicon)
OST382598 (lexicon) OST380292 (lexicon) OST375262 (lexicon) OST374370 (lexicon)
OST357671 (lexicon) OST335210 (lexicon) OST328915 (lexicon) OST295859 (lexicon)
OST224044 (lexicon) OST221735 (lexicon) OST85733 (lexicon) OST77541 (lexicon)
OST55756 (lexicon) OST50043 (lexicon)
Severity of mutation (?) Insertion after 7% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI15939
Vector Insertion
Chr 2: 160508511 - 160510183
Public Clones not available
Private Clones OST469888 (lexicon) OST360616 (lexicon) OST335256 (lexicon) OST328908 (lexicon)
OST324760 (lexicon) OST79322 (lexicon)
Severity of mutation (?) Insertion after 12% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI901
Vector Insertion
Chr 2: 160510240 - 160513383
Public Clones BC0497 (sanger)
Private Clones OST48441 (lexicon)
Severity of mutation (?) Insertion after 15% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI556
Vector Insertion
Chr 2: 160513480 - 160516012
Public Clones BC0168 (sanger)
Private Clones OST234102 (lexicon) OST34619 (lexicon)
Severity of mutation (?) Insertion after 19% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI5513
Vector Insertion
Chr 2: 160519539 - 160523859
Public Clones YTA111 (baygenomics)
Private Clones not available
Severity of mutation (?) Insertion after 27% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI6683
Vector Insertion
Chr 2: 160523976 - 160528437
Public Clones BGC379 (baygenomics) XH071 (baygenomics)
Private Clones not available
Severity of mutation (?) Insertion after 32% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI3321
Vector Insertion
Chr 2: 160531058 - 160538380
Public Clones AD0078 (sanger) RRR124 (baygenomics) W024C12 (ggtc)
Private Clones not available
Severity of mutation (?) Insertion after 57% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI1786
Vector Insertion
Chr 2: 160538525 - 160539816
Public Clones CD0264 (sanger)
Private Clones not available
Severity of mutation (?) Insertion after 63% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

UniTrap UNI4152
Vector Insertion
Chr 2: 160543251 - 160546314
Public Clones AM0923 (sanger)
Private Clones not available
Severity of mutation (?) Insertion after 85% of polypeptide chain
Proposed experimental design for vector insertion validation (?)

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